Skip to Content
Find More Like This
Return to Search

Method for identifying and quantifying nucleic acid sequence aberrations

United States Patent

5,783,387
July 21, 1998
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A method for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe.
Lucas; Joe N. (San Ramon, CA), Straume; Tore (Tracy, CA), Bogen; Kenneth T. (Walnut Creek, CA)
The Regents of the University of California (Oakland, CA)
08/ 384,497
February 6, 1995
The United States government has rights in this invention pursuant to Contract Number W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.