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Triggered pore-forming agents

United States Patent

5,777,078
July 7, 1998
View the Complete Patent at the US Patent & Trademark Office
An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.
Bayley; Hagan (Grafton, MA), Walker; Barbara J. (Auburn, MA), Chang; Chung-yu (Worcester, MA), Niblack; Brett (Nashville, TN), Panchal; Rekha (Shrewsbury, MA)
Worcester Foundation for Experimental Biology (Shrewsbury, MA)
08/ 478,913
June 7, 1995
STATEMENT AS TO FEDERALLY SPONSORED RESEARCH This invention was made with Government support under Grant No. DE-FG02-90ER20018 awarded by the Department of Energy, co-sponsored by the Division of Energy Biosciences and the Division of Materials Sciences, Grant No. N00014-93-1-0962 awarded by the Office of Naval Research, and Grant No. R01 NS26760 awarded by the National Institutes of Health. The Government has certain rights in the invention.