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Mutant E. coli strain with increased succinic acid production

United States Patent

5,770,435
June 23, 1998
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which as been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria.
Donnelly; Mark (Warrenville, IL), Millard; Cynthia S. (Plainfield, IL), Stols; Lucy (Woodridge, IL)
University of Chicago (Chicago, IL)
08/ 556,805
November 2, 1995
CONTRACTUAL ORIGIN OF THE INVENTION The United States Government has rights in this invention under Contract No. W-31-109-ENG-38 between the U.S. Department of Energy and the University of Chicago representing Argonne National Laboratory.