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Antibody-mediated reduction of .alpha.-ketoamides

United States Patent

5,763,249
June 9, 1998
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Monoclonal antibodies raised against a 4-nitrophenyl phosphonate hapten catalyze the stereospecific reduction of an .alpha.-ketoamide to the corresponding .alpha.-hydroxyamide in the presence of an appropriate reducing agent.
Schultz; Peter G. (Oakland, CA), Gallop; Mark A. (East Palo Alto, CA)
The Regents of the University of California (Oakland, CA)
07/ 805,502
December 9, 1991
This invention lies in the field of the use of antibodies as catalysts in chemical reactions. This invention was made with Government support under Contract No. DE-AC03-SF-00098 awarded by the Department of Energy. The Government has certain rights in this invention.