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Modified acyl-ACP desaturase

United States Patent

*** EXPIRED ***
January 6, 1998
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Disclosed is a methods for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
Cahoon; Edgar B. (Shoreham, NY), Shanklin; John (Shoreham, NY), Lindgvist; Ylva (Jarfalla, SE), Schneider; Gunter (Jarfalla, SE)
Associated Universities, Inc. (Washington, DC)
08/ 689,823
August 14, 1996
This invention was made with Government support under Contract No. DE-AC02-76CH-00016 awarded by the Department of Energy. The Government has certain rights in this invention.