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Nucleotide sequences encoding a thermostable alkaline protease

United States Patent

5,705,379
January 6, 1998
View the Complete Patent at the US Patent & Trademark Office
Nucleotide sequences, derived from a thermophilic actinomycete microorganism, which encode a thermostable alkaline protease are disclosed. Also disclosed are variants of the nucleotide sequences which encode a polypeptide having thermostable alkaline proteolytic activity. Recombinant thermostable alkaline protease or recombinant polypeptide may be obtained by culturing in a medium a host cell genetically engineered to contain and express a nucleotide sequence according to the present invention, and recovering the recombinant thermostable alkaline protease or recombinant polypeptide from the culture medium.
Wilson; David B. (Ithaca, NY), Lao; Guifang (Bethesda, MD)
Cornell Research Foundation, Inc. (Ithaca, NY)
08/ 736,361
October 23, 1996
This invention was made with government support under grant DE-F G02-13233 from the Department of Energy. The government has certain rights in the invention.