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Nuclear magnetic resonance contrast agents

United States Patent

5,702,683
December 30, 1997
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC.sub.16 H.sub.14 N.sub.6. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques.
Smith; Paul H. (Los Alamos, NM), Brainard; James R. (Los Alamos, NM), Jarvinen; Gordon D. (Los Alamos, NM), Ryan; Robert R. (Los Alamos, NM)
The United States of America as represented by the United States (Washington, DC)
07/ 643,092
January 22, 1991
The invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy to The Regents of the University of California. The government has certain rights in the invention.