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Probes labelled with energy transfer coupled dyes

United States Patent

5,688,648
November 18, 1997
View the Complete Patent at the US Patent & Trademark Office
Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
Mathies; Richard A. (El Cerrito, CA), Glazer; Alexander (Orinda, CA), Ju; Jingyue (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
08/ 574,890
December 19, 1995
This invention was made with Government support under Grant (Contract) No. DE-FG03-91ER61125 from the U.S. Department of Energy. The Government has certain rights to this invention.