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Thermostable cellulase from a thermomonospora gene

United States Patent

5,677,151
October 14, 1997
View the Complete Patent at the US Patent & Trademark Office
The invention relates to a gene isolated from Thermomonospora fusca, wherein the gene encodes a thermostable cellulase. Disclosed is the nucleotide sequence of the T. fusca gene; and nucleic acid molecules comprising the gene, or a fragment of the gene, that can be used to recombinantly express the cellulase or a catalytically active polypeptide thereof, respectively. The isolated and purified recombinant cellulase or catalytically active polypeptide may be used to hydrolyze substrate either by itself; or in combination with other cellulases, with the resultant combination having unexpected hydrolytic activity.
Wilson; David B. (Ithaca, NY), Walker; Larry P. (Ithaca, NY), Zhang; Sheng (Ithaca, NY)
Cornell Research Foundation, Inc. (Ithaca, NY)
08/ 265,429
June 24, 1994
This invention was made with government support under grant number FG02-84ER13233 awarded by the United States Department of Energy. The government has certain rights in this invention.