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Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

United States Patent

5,633,129
May 27, 1997
View the Complete Patent at the US Patent & Trademark Office
The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability.
Karger; Barry L. (Newton, MA), Thilly; William G. (Winchester, MA), Foret; Frantisek (Malden, MA), Khrapko; Konstaintin (Brookline, MA), Koehavong; Phouthone (Pittsburgh, PA), Cohen; Aharon S. (Newton, MA), Giese; Roger W. (Quincy, MA)
Massachusetts Institute of Technology (Cambridge, MA), Northeastern University (Boston, MA)
08/ 190,919
February 3, 1994
GOVERNMENT FUNDING Work described herein was supported by grants from the U.S. National Institute for Environmental Health Sciences and the Department of Energy. The United States Government has certain rights in this invention.