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TGF-.beta. antagonists as mitigators of radiation-induced tissue damage

United States Patent

5,616,561
April 1, 1997
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A method for treating tissue damage caused by radiation is described by use of a TGF-.beta. antagonist, such as an anti-TGF-.beta. antibody or a TGF-.beta. latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.
Barcellos-Hoff; Mary H. (Oakland, CA)
Regents of the University of California (Oakland, CA)
08/ 414,020
March 31, 1995
The United States Government has certain rights to this invention pursuant to contract No. DE-AC03-76SF00098 between the U.S. Department of Energy and the University of California for the operation of Lawrence Berkeley Laboratory.