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DNA polymerase having modified nucleotide binding site for DNA sequencing

United States Patent

5,614,365
March 25, 1997
View the Complete Patent at the US Patent & Trademark Office
Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.
Tabor; Stanley (Cambridge, MA), Richardson; Charles (Chestnut Hill, MA)
President & Fellow of Harvard College (Cambridge, MA)
08/ 337,615
November 10, 1994
This invention was made with government support including a grant from the U.S. Dept of Energy, contract number DE-FG02-88ER60688. The U.S. government may have certain rights in the invention.