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Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

United States Patent

5,612,017
March 18, 1997
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
Miura; Michiko (Hampton Bays, NY), Slatkin; Daniel N. (Southold, NY)
Associated Universities, Inc. (Washington, DC)
08/ 427,673
April 24, 1995
This invention was made with U.S. Government support under Department of Energy Contract Number DE AC02-76CH00016 and under National Institutes of Health Grant Number IR01CA38107-01A2. The U.S. Government has certain rights in the invention.