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Human MSH2 protein

United States Patent

5,591,826
January 7, 1997
View the Complete Patent at the US Patent & Trademark Office
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
de la Chapelle; Albert (Helsingfors, FI), Vogelstein; Bert (Baltimore, MD), Kinzler; Kenneth W. (Baltimore, MD)
The Johns Hopkins University (Baltimore, MD)
08/ 457,176
June 1, 1995
This invention was made using U.S. government grants form the NIH CA47527, CA09320, GM26449, CA09243, CA41183, CA42705 CA57435, and CA35494, as well as grants from the Department of Energy DOE/ERN/F139 and DE-FG 09291ER-61139. Therefore the U.S. government retains certain rights to the invention.