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Multiplexed capillary electrophoresis system

United States Patent

5,582,705
December 10, 1996
View the Complete Patent at the US Patent & Trademark Office
Ames Laboratory - Visit the Iowa State University Research Foundation - Office of Intellectual Property & Technology Transfer Website
The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the array such that the interior of a capillary is imaged onto only one pixel. In Sanger-type 4-label DNA sequencing reactions, nucleotide identification ("base calling") is improved by using two long-pass filters to split fluorescence emission into two emission channels. A binary poly(ethyleneoxide) matrix is used in the electrophoretic separations.
Yeung; Edward S. (Ames, IA), Chang; Huan-Tsang (Silver Spring, MD), Fung; Eliza N. (Ames, IA), Li; Qingbo (Ames, IA), Lu; Xiandan (Ames, IA)
Iowa State University Research Foundation, Inc. (Ames, IA)
08/ 444,565
May 19, 1995
GOVERNMENT RIGHTS This invention was made with government support under Contract No. W-7405-Eng-82 awarded by the U.S. Department of Energy. The Government has certain rights in this invention.