Skip to Content
Find More Like This
Return to Search

Use of galerina marginata genes and proteins for peptide production

United States Patent

April 3, 2018
View the Complete Patent at the US Patent & Trademark Office
The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
Hallen-Adams; Heather E. (Lincoln, NE), Scott-Craig; John S. (East Lansing, MI), Walton; Jonathan D. (East Lansing, MI), Luo; Hong (East Lansing, MI)
Board of Trustees of Michigan State University (East Lansing, MI)
15/ 437,359
February 20, 2017
GOVERNMENT INTERESTS This invention was made with government support under DE-FG02-91ER20021, awarded by the U.S. Department of Energy. The government has certain rights in the invention.