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Discovery, detection and use of biomarkers

United States Patent

9,835,618
December 5, 2017
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Provided herein are systems for and methods of capturing, detecting, quantifying, and characterizing target moieties that are characterized by having a lipophilic portion of sufficient size and chemical composition whereby the target moiety inserts (or partitions) into a lipid assembly. Examples of such assays employ synthetic lipid constructs such as supported bilayers which are used to capture target moieties; other example assays exploit the natural absorption of compounds into natural lipid constructs such as HDL or LDL particles or cell membranes to capture target moieties. In specific embodiments, the target moieties are bacterial pathogen associated molecular pattern (PAMP) molecules or compounds not yet identified as PAMP molecules. Also provided are methods of determining PAMP molecule fingerprints and profiles that are linked to (indicative of) bacterial infection, disease states or progression, development of antibiotic resistance, and so forth, as well as these fingerprints, profiles and methods of using them.
Swanson; Basil I. (Los Alamos, NM), Mukundan; Harshini (Los Alamos, NM), Sakamuri; Rama Murthy (Los Alamos, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
13/ 529,847
June 21, 2012
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the United States Department of Energy. The government has certain rights in the invention.