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Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them

United States Patent

9,834,775
December 5, 2017
View the Complete Patent at the US Patent & Trademark Office
Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.
Church; George M. (Brookline, MA), Mandell; Daniel J. (Brookline, MA), Lajoie; Marc J. (Cambridge, MA)
President and Fellows of Harvard College (Cambridge, MA)
15/ 025,406
20160230176
September 26, 2014
STATEMENT OF GOVERNMENT INTERESTS This invention was made with government support under EEC-0540879 awarded by National Science Foundation and under DE-FG02-02ER63445 awarded by U.S. Department of Energy and under N66001-12-C-4040 awarded by U.S. Department of Defense Space and Naval Warfare Systems Command. The Government has certain rights in the invention.