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System, apparatus, and method for simultaneous single molecule atomic force microscopy and fluorescence measurements

United States Patent

8,656,510
February 18, 2014
View the Complete Patent at the US Patent & Trademark Office
Microscope for Simultaneous Single Molecule AFM and Fluorescence Measurements
An apparatus, system, and method of integrating atomic force microscopy (AFM) and fluorescence microscopy (FM). One particular application is to simultaneous single molecular fluorescence with AFM force spectroscopy. Included is a methodology to align the AFM tip and a molecule or other nanoscale object with high accuracy.
Sivasankar; Sanjeevi (Ames, IA), Li; Hui (Ames, IA)
Iowa State University Research Foundation, Inc. (Ames, IA)
13/ 569,927
August 8, 2012