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Sorting process of nanoparticles and applications of same

United States Patent

9,802,818
October 31, 2017
View the Complete Patent at the US Patent & Trademark Office
In one aspect of the present invention, a method for sorting nanoparticles includes preparing a high-viscosity density gradient medium filled in a container, dispersing nanoparticles into an aqueous solution to form a suspension of the nanoparticles, each nanoparticle having one or more cores and a shell encapsulating the one or more cores, layering the suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container, and centrifugating the layered suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container at a predetermined speed for a predetermined period of time to form a gradient of fractions of the nanoparticles along the container, where each fraction comprises nanoparticles in a respective one of aggregation states of the nanoparticles.
Tyler; Timothy P. (Chicago, IL), Henry; Anne-Isabelle (Chicago, IL), Van Duyne; Richard P. (Wilmette, IL), Hersam; Mark C. (Wilmette, IL)
NORTHWESTERN UNIVERSITY (Evanston, IL)
13/ 461,521
20120281213
May 1, 2012
STATEMENT OF FEDERALLY-SPONSORED RESEARCH This invention was made with government support under FA9550-08-1-0221 awarded by the Air Force Office of Scientific Research, DE-SC0001059 awarded by the Department of Energy, and CHE0911145, DMR0520513, and DMR1006391 awarded by the National Science Foundation. The government has certain rights in the invention.