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Devices, systems, and methods for detecting nucleic acids using sedimentation

United States Patent

9,795,961
October 24, 2017
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
Embodiments of the present invention are directed toward devices, systems, and method for conducting nucleic acid purification and quantification using sedimentation. In one example, a method includes generating complexes which bind to a plurality of beads in a fluid sample, individual ones of the complexes comprising a nucleic acid molecule such as DNA or RNA and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
Koh; Chung-Yan (Dublin, CA), Schaff; Ulrich Y. (Livermore, CA), Sommer; Gregory J. (Livermore, CA)
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
13/ 423,008
March 16, 2012
STATEMENT REGARDING RESEARCH & DEVELOPMENT Described examples were made with Government support under Government Contract No. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention, including a paid-up license and the right, in limited circumstances, to require the owner of any patent issuing in this invention to license others on reasonable terms.