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Methods for the selective detection of alkyne-presenting molecules and related compositions and systems

United States Patent

9,791,463
October 17, 2017
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems. The methods include contacting a detection reagent with the sample for a time and under a condition to allow binding of the detection reagent to the one or more alkyne-presenting molecules possibly present in the matrix to the detection reagent. The detection reagent includes an organic label moiety presenting an azide group. The binding of the azide group to the alkyne-presenting molecules results in emission of a signal from the organic label moiety.
Valdez; Carlos A. (San Ramon, CA), Vu; Alexander K. (Dublin, CA)
Lawrence Livermore National Security, LLC (Livermore, CA)
14/ 201,530
20140273274
March 7, 2014
STATEMENT OF GOVERNMENT GRANT The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the United States Department of Energy and Lawrence Livermore National Security, LLC for the operation of Lawrence Livermore National Laboratory.