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Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry

United States Patent

9,793,477
October 17, 2017
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
Wang; Daojing (Moraga, CA), Mao; Pan (Fremont, CA), Wang; Hung-Ta (Tuscaloosa, AL), Yang; Peidong (Kensington, CA)
The Regents of The University of California (Oakland, CA)
14/ 137,840
20140110661
December 20, 2013
STATEMENT OF GOVERNMENTAL SUPPORT The invention was made with government support under Contract Nos. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and Grant R21GM077870 awarded by the National Institutes of Health. The government has certain rights in the invention.