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Biosensors engineered from conditionally stable ligand-binding domains

United States Patent

9,766,255
September 19, 2017
View the Complete Patent at the US Patent & Trademark Office
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.
Church; George M. (Brookline, MA), Feng; Justin (Cambridge, MA), Mandell; Daniel J. (Brookline, MA), Baker; David (Seattle, WA), Fields; Stanley (Seattle, WA), Jester; Benjamin Ward (Seattle, WA), Tinberg; Christine Elaine (Seattle, WA)
President and Fellows of Harvard College (Cambridge, MA), University of Washington (Seattle, WA)
14/ 993,509
January 12, 2016
STATEMENT OF GOVERNMENT INTERESTS This invention was made with government support under HDTRA-1-10-1-0040 and N-00024-10-D-6318/0024 awarded by U.S. Department of Defense, and under DE-FG02-02ER63445 awarded by U.S. Department of Energy, and under GM103533 awarded by National Institutes of Health. The government has certain rights in the invention.