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System and method for detecting components of a mixture including a valving scheme for competition assays

United States Patent

9,766,230
September 19, 2017
View the Complete Patent at the US Patent & Trademark Office
Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.
Koh; Chung-Yan (Dublin, CA), Piccini; Matthew E. (Belmont, CA), Singh; Anup K. (Danville, CA)
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
15/ 616,740
20170269072
June 7, 2017
STATEMENT REGARDING RESEARCH & DEVELOPMENT This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The U.S. Government has certain rights in the invention.