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Compositions containing amino acids, phosphate and manganese and their uses

United States Patent

9,758,760
September 12, 2017
View the Complete Patent at the US Patent & Trademark Office
The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.
Daly; Michael J. (Washington, DC), Gaidamakova; Elena K. (Gaithersburg, MD)
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, MD)
14/ 962,596
20160222343
December 8, 2015
GOVERNMENT SUPPORT This invention was made with government support under DE-FG02-04ER63918 and FA9550-07-1-0218 awarded by Department of Energy and Air Force Office of Scientific Research, respectively. The government has certain rights in the invention.