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Microneedle arrays for biosensing and drug delivery

United States Patent

9,743,870
August 29, 2017
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.
Wang; Joseph (San Diego, CA), Windmiller; Joshua Ray (Del Mar, CA), Narayan; Roger (Raleigh, NC), Miller; Philip (Greensboro, NC), Polsky; Ronen (Albuquerque, NM), Edwards; Thayne L. (Albuquerque, NM)
The Regents of the University of California (Oakland, CA), North Carolina State University (Raleigh, NC), National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
14/ 965,755
December 10, 2015
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under grants no. N00014-08-1-1202 awarded by the Office of Naval Research (ONR), grant no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation, and grant no. 151337 awarded by Sandia National Laboratories Laboratory Directed Research and Development (LDRD). The government has certain rights in the invention.