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Expression of enzymes in yeast for lignocellulose derived oligomer CBP

United States Patent

August 29, 2017
View the Complete Patent at the US Patent & Trademark Office
The present invention provides a multi-component enzyme system that hydrolyzes hemicellulose oligomers from hardwood which can be expressed, for example, in yeast such as Saccharomyces cerevisiae. In some embodiments, this invention provides for the engineering of a series of biocatalysts combining the expression and secretion of components of this enzymatic system with robust, rapid xylose utilization, and ethanol fermentation under industrially relevant process conditions for consolidated bioprocessing. In some embodiments, the invention utilizes co-cultures of strains that can achieve significantly improved performance due to the incorporation of additional enzymes in the fermentation system.
McBride; John E. (Lyme, NH), Wiswall; Erin (Danbury, NH), Shikhare; Indraneel (Houston, TX), Xu; Haowen (Yorktown Heights, NY), Thorngren; Naomi (Norwich, VT), Hau; Heidi H. (St. Paul, MN), Stonehouse; Emily (Lebanon, NH)
Lallemand Hungary Liquidity Management LLC (Budapest, HU)
14/ 424,560
March 15, 2013
STATEMENT REGARDING FEDERALLY-SPONSORED RESEARCH AND DEVELOPMENT This invention was funded, in part, by the United States government under a grant with the Department of Energy, Award No. DE-FC36-08G018103. This invention was also funded, in part, by the Bioenergy Science Center, Oak Ridge National Laboratory, a U.S. Department of Energy Bioenergy Research Center supported by the Office of Biological and Environmental Research, under contract DE-PS02-06ER64304. The U.S. Government has certain rights in this invention.