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Tricyclic gyrase inhibitors

United States Patent

9,732,083
August 15, 2017
View the Complete Patent at the US Patent & Trademark Office
Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
Bensen; Daniel (Carlsbad, CA), Chen; Zhiyong (San Diego, CA), Finn; John (Encinitas, CA), Lam; Thanh To (San Diego, CA), Lee; Suk Joong (San Diego, CA), Li; Xiaoming (San Diego, CA), Phillipson; Douglas W. (Del Mar, CA), Tari; Leslie William (San Diego, CA), Trzoss; Michael (San Diego, CA), Zhang; Junhu (San Diego, CA), Lightstone; Felice C. (Fremont, CA), Nguyen; Toan B. (San Ramon, CA), Wong; Sergio E. (San Jose, CA), Aristoff; Paul (Dexter, MI), Jung; Michael (Los Angeles, CA)
MERCK SHARP & DOHME CORP. (New York, NY), LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, CA)
13/ 496,188
20120238751
March 14, 2012
STATEMENT REGARDING FEDERALLY SPONSORED R&D This claimed invention was made with government support under Contract No. HHSN272200800042C awarded by the National Institute of Allergy and Infectious Diseases. The government has certain rights in the invention. PARTIES OF JOINT RESEARCH AGREEMENT The claimed invention was made pursuant to a joint research agreement between Trius Therapeutics, Inc. and Lawrence Livermore National Security, LLC under its United States Department of Energy Contract No. TC02128.0.