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Thionin-D4E1 chimeric protein protects plants against bacterial infections

United States Patent

9,725,734
August 8, 2017
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The generation of a chimeric protein containing a first domain encoding either a pro-thionon or thionin, a second domain encoding D4E1 or pro-D4E1, and a third domain encoding a peptide linker located between the first domain and second domain is described. Either the first domain or the second domain is located at the amino terminal of the chimeric protein and the other domain (second domain or first domain, respectively) is located at the carboxyl terminal. The chimeric protein has antibacterial activity. Genetically altered plants and their progeny expressing a polynucleotide encoding the chimeric protein resist diseases caused by bacteria.
Stover; Eddie W (Fort Pierce, FL), Gupta; Goutam (Santa Fe, NM), Hao; Guixia (Fort Pierce, FL)
The United States of America, as represented by the Secretary of Agriculture (Washington, DC), Los Alamos National Security, LLC (Los Alamos, NM)
14/ 691,780
20160312241
April 21, 2015
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The United States government has rights in this invention pursuant to Contract No. DE-AC52-06NA25396 between the United States Department of Energy and Los Alamos National Security, LLC for the operation of Los Alamos National Laboratory.