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De novo design of allosteric proteins

United States Patent

9,721,061
August 1, 2017
View the Complete Patent at the US Patent & Trademark Office
Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
Raman; Srivatsan (Arlington, MA), Taylor; Noah D. (Boston, MA), Church; George M. (Brookline, MA)
President and Fellows of Harvard College (Cambridge, MA)
15/ 120,228
20170132358
February 20, 2015
STATEMENT OF GOVERNMENT INTERESTS This invention was made with government support under DE-FG02-02ER63445 awarded by the U.S. Department of Energy. The government has certain rights in this invention.