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Cells and methods for producing fatty alcohols

United States Patent

9,708,630
July 18, 2017
View the Complete Patent at the US Patent & Trademark Office
Recombinant cells and methods for improved yield of fatty alcohols. The recombinant cells harbor a recombinant thioesterase gene, a recombinant acyl-CoA synthetase gene, and a recombinant acyl-CoA reductase gene. In addition, a gene product from one or more of an acyl-CoA dehydrogenase gene, an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase gene, and a 3-ketoacyl-CoA thiolase gene in the recombinant cells is functionally deleted. Culturing the recombinant cells produces fatty alcohols at high yields.
Pfleger; Brian F. (Madison, WI), Youngquist; J. Tyler (Medina, OH)
WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, WI)
14/ 509,408
October 8, 2014
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with government support under DE-FC02-07ER64494 awarded by the US Department of Energy. The government has certain rights in the invention.