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Positive modulator of bone morphogenic protein-2

United States Patent

9,670,258
June 6, 2017
View the Complete Patent at the US Patent & Trademark Office
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
Zamora; Paul O. (Gaithersburg, MD), Pena; Louis A. (Poquott, NY), Lin; Xinhua (Plainview, NY), Kazuyuki; Takahashi (Germantown, MD)
Ferring B.V. (Hoofddorp, NL), Brookhaven Science Associates, LLC (Upton, NY)
15/ 240,977
20160376334
August 18, 2016
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with United States Government support under contract number DE-ACO2-98CH1086, awarded by the U.S. Department of Energy. The United States Government has certain rights in the invention.