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Apolipoprotein nanodiscs with telodendrimer

United States Patent

9,644,038
May 9, 2017
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
Luo; Juntao (Jamesville, NY), He; Wei (Davis, CA), Lam; Kit S. (Davis, CA), Henderson; Paul (Dublin, CA), Coleman; Matthew (Oakland, CA), Cheng; R. Holland (Davis, CA), Xing; Li (Davis, CA)
The Regents of the University of California (Oakland, CA), Lawrence Livermore National Security, LLC (Livermore, CA)
13/ 719,785
December 19, 2012
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with Government support under Grant No. R01 CA115483, awarded by the National Institute of Health, and Contract No. DE-AC52-07NA27344 between the United States Department of Energy and Lawrence Livermore National Security, LLC for the operation of Lawrence Livermore National Laboratory. The Government has certain rights in this invention.