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Formation of stable submicron peptide or protein particles by thin film freezing

United States Patent

9,622,974
April 18, 2017
View the Complete Patent at the US Patent & Trademark Office
The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.
Johnston; Keith P. (Austin, TX), Engstrom; Joshua (Spotswood, NJ), Williams, III; Robert O. (Austin, TX)
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS (Austin, TX)
14/ 603,211
January 22, 2015
STATEMENT AS TO FEDERALLY SPONSORED RESEARCH This invention was made with government support under Grant No. AA-FG02-04ER15549 awarded by the Department of Energy. The government has certain rights in the invention.