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Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate

United States Patent

9,605,269
March 28, 2017
View the Complete Patent at the US Patent & Trademark Office
One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
Sillers; William Ryan (Lebanon, NH), Van Dijken; Hans (Schiedam HG, NL), Licht; Steve (Utica, NY), Shaw, IV; Arthur J. (Grantham, NH), Gilbert; Alan Benjamin (Lebanon, NH), Argyros; Aaron (White River Junction, VT), Froehlich; Allan C. (Lebanon, NH), McBride; John E. (Lyme, NH), Xu; Haowen (Lebanon, NH), Hogsett; David A. (Lebanon, NH), Rajgarhia; Vineet B. (Lebanon, NH)
Lallemand Hungary Liquidity Management LLC (Budapest, HU)
13/ 696,207
May 5, 2011
U.S. GOVERNMENT SUPPORT This invention was partially made with government support under Department of Energy Grants GO18103 and GO17057. The government has certain rights in the invention.