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Use of Galerina marginata genes and proteins for peptide production

United States Patent

9,598,686
March 21, 2017
View the Complete Patent at the US Patent & Trademark Office
The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
Hallen-Adams; Heather E. (Lincoln, NE), Scott-Craig; John S. (East Lansing, MI), Walton; Jonathan D. (East Lansing, MI), Luo; Hong (East Lansing, MI)
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, MI)
14/ 933,239
20160281075
November 5, 2015
GOVERNMENT INTERESTS This invention was made in part with government support under DE-FG02-91ER20021 awarded by the United States Department of Energy. The Government has certain rights in the invention.