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Sequestration of carbon dioxide with hydrogen to useful products

United States Patent

9,587,256
March 7, 2017
View the Complete Patent at the US Patent & Trademark Office
Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
Adams; Michael W. W. (Athens, GA), Kelly; Robert M. (Cary, NC), Hawkins; Aaron B. (Durham, NC), Menon; Angeli Lal (Athens, GA), Lipscomb; Gina Lynette Pries (Athens, GA), Schut; Gerrit Jan (Athen, GA)
University of Georgia Research Foundation, Inc. (Athens, GA), North Carolina State University (Raleigh, NC)
14/ 426,290
20150211030
September 6, 2013
GOVERNMENT FUNDING The present invention was made with government support under Grant No. DE-AR0000081, awarded by the Department of Energy. The government has certain rights in this invention.