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Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

United States Patent

March 7, 2017
View the Complete Patent at the US Patent & Trademark Office
Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
Church; George M. (Brookline, MA), Esvelt; Kevin (Auburndale, MA), Mali; Prashant (Somerville, MA)
President and Fellows of Harvard College (Cambridge, MA)
14/ 674,895
March 31, 2015
STATEMENT OF GOVERNMENT INTERESTS This invention was made with government support under Grant No. P50 HG005550 from the National Institutes of health and DE-FG02-02ER63445 from the Department of Energy. The government has certain rights in the invention.