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Systems and methods for the secretion of recombinant proteins in gram negative bacteria

United States Patent

9,574,197
February 21, 2017
View the Complete Patent at the US Patent & Trademark Office
Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant E. coli strains containing expression vectors carrying nucleic acids encoding the proteins, and secretory signal sequences to direct the secretion of the proteins to the culture medium. Host cells transformed with the expression vectors are also provided.
Withers, III; Sydnor T. (Madison, WI), Dominguez; Miguel A. (Madison, WI), DeLisa; Matthew P. (Ithaca, NY), Haitjema; Charles H. (Ithaca, NY)
WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, WI), CORNELL UNIVERSITY (Ithaca, NY)
15/ 211,632
20160333360
July 15, 2016
STATEMENT OF GOVERNMENT SUPPORT This invention was made with government support under DE-FC02-07ER64494 awarded by the U.S. Department of Energy. The government has certain rights in the invention.