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Cellulase variants with improved expression, activity and stability, and use thereof

United States Patent

December 20, 2016
View the Complete Patent at the US Patent & Trademark Office
The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
Aehle; Wolfgang (Zwingenberg, DE), Bott; Richard R. (Burlingame, CA), Bower; Benjamin S. (Newark, CA), Caspi; Jonathan (Sunnyvale, CA), Estell; David A. (San Francisco, CA), Goedegebuur; Frits (Vlaardingen, NL), Hommes; Ronaldus Wilhelmus Joannes (Haarlem, NL), Kaper; Thijs (Half Moon Bay, CA), Kelemen; Bradley R. (Menlo Park, CA), Kralj; Slavko (Oegstgeest, NL), Van Lieshout; Johannes Franciscus Thomas (Utrecht, NL), Nikolaev; Igor (Noordwijk, NL), Van Stigt Thans; Sander (Zevenbergen, NL), Wallace; Louise (Redwood City, CA), Vogtentanz; Gudrun (Sunnyvale, CA), Sandgren; Mats (Uppsala, SE)
14/ 189,943
February 25, 2014
This invention was made with Government support under conditional award no: DE-FC36-08GO18078 awarded by the Department of Energy. The Government has certain rights in this invention.