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Identification and use of genes encoding amatoxin and phallotoxin

United States Patent

9,518,097
December 13, 2016
View the Complete Patent at the US Patent & Trademark Office
The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the present invention also relates to methods for detecting Amanita peptide toxin genes for identifying Amanita peptide-producing mushrooms and for diagnosing suspected cases of mushroom poisoning. Further, the present inventions relate to providing kits for diagnosing and monitoring suspected cases of mushroom poisoning in patients.
Hallen; Heather E. (Lincoln, NE), Walton; Jonathan D. (East Lansing, MI), Luo; Hong (Lansing, MI), Scott-Craig; John S. (East Lansing, MI)
Board of Trustees of Michigan State University (East Lansing, MI)
12/ 268,229
20100267019
November 10, 2008
GOVERNMENT INTERESTS This invention was made with government support under DE-FG02-91ER20021 awarded by the U.S. Department of Energy. The government has certain rights in the invention.