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Miniature acoustic wave lysis system and uses thereof

United States Patent

9,512,421
December 6, 2016
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
The present invention relates to an acoustic lysis system including a disposable cartridge that can be reversibly coupled to a platform having a small, high-frequency piezoelectric transducer array. In particular, the system releases viable DNA, RNA, and proteins from human or bacterial cells, without chemicals or additional processing, to enable high-speed sample preparation for clinical point-of-care medical diagnostics and use with nano/microfluidic cartridges. Also described herein are methods of making and using the system of the invention.
Branch; Darren W. (Albuquerque, NM), Vreeland; Erika Cooley (Albuquerque, NM), Smith; Gennifer Tanabe (Albuquerque, NM)
Sandia Corporation (Albuquerque, NM)
14/ 318,364
June 27, 2014
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.