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Methods of treating Parkinson's disease using viral vectors

United States Patent

9,492,415
November 15, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.
Bankiewicz; Krystof (Garrett Park, MD), Cunningham; Janet (Alameda, CA)
Genzyme Corporation (Framingham, MA), The Regents of the University of California (Oakland, CA)
13/ 647,155
20130101510
October 8, 2012
REFERENCE TO GOVERNMENT RIGHTS Part of this work was made under the auspices of the U.S. Department of Energy, at the University of California/Lawrence Berkeley National Laboratory, under CRADA No. BG98039 and DOE Contract No. DE-AC03-76SF00098, now Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.