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Long-range barcode labeling-sequencing

United States Patent

9,469,874
October 18, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods for sequencing single large DNA molecules by clonal multiple displacement amplification using barcoded primers. Sequences are binned based on barcode sequences and sequenced using a microdroplet-based method for sequencing large polynucleotide templates to enable assembly of haplotype-resolved complex genomes and metagenomes.
Chen; Feng (Castro Valley, CA), Zhang; Tao (San Diego, CA), Singh; Kanwar K. (Pittsburg, CA), Pennacchio; Len A. (Sebastopol, CA), Froula; Jeff L. (Walnut Creek, CA), Eng; Kevin S. (San Francisco, CA)
The Regents of the University of California (Oakland, CA)
13/ 653,343
20130130919
October 16, 2012
STATEMENT REGARDING GOVERNMENTAL SUPPORT This invention was made with Government support under Contract No. DE-AC02-05CH11231 awarded by the Department of Energy. The Government has certain rights in the invention.