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Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification

United States Patent

October 4, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Provided herein are methods and systems for assembling, solubilizing and/or purifying a membrane associated protein in a nanolipoprotein particle, which comprise a temperature transition cycle performed in presence of a detergent, wherein during the temperature transition cycle the nanolipoprotein components are brought to a temperature above and below the gel to liquid crystalling transition temperature of the membrane forming lipid of the nanolipoprotein particle.
Chromy; Brett A. (Danville, CA), Henderson; Paul (Dublin, CA), Hoeprich, Jr.; Paul D. (Pleasanton, CA)
Lawrence Livermore National Security, LLC (Livermore, CA)
14/ 536,513
November 7, 2014
STATEMENT OF GOVERNMENT GRANT The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the U.S. Department of Energy and Lawrence Livermore National Security, LLC.