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Radioisotope trithiol complexes

United States Patent

9,427,483
August 30, 2016
View the Complete Patent at the US Patent & Trademark Office
The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.
Jurisson; Silvia S. (Columbia, MO), Cutler; Cathy S. (Columbia, MO), Degraffenreid; Anthony J. (Columbia, MO)
THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, MO)
14/ 679,520
20150283274
April 6, 2015
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Government support under Grant No. DE-SC0003 85 1 awarded by the Department of Energy. The Government has certain rights in the invention.