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Modified host cells with efflux pumps

United States Patent

August 30, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a modified host cell comprising a heterologous expression of an efflux pump capable of transporting an organic molecule out of the host cell wherein the organic molecule at a sufficiently high concentration reduces the growth rate of or is lethal to the host cell.
Dunlop; Mary J. (Burlington, VT), Keasling; Jay D. (Berkeley, CA), Mukhopadhyay; Aindrila (San Francisco, CA)
The Regents of the University of California (Oakland, CA)
13/ 115,925
May 25, 2011
STATEMENT OF GOVERNMENTAL SUPPORT The invention described and claimed herein was made in part utilizing funds supplied by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.