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Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual

United States Patent

August 9, 2016
View the Complete Patent at the US Patent & Trademark Office
Idaho National Laboratory - Visit the Technology Transfer and Commercialization Office Website
A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.
Apel; William A. (Jackson, WY), Thompson; Vicki S. (Idaho Falls, ID), Lacey; Jeffrey A. (Idaho Falls, ID), Gentillon; Cynthia A. (Idaho Falls, ID)
Battelle Energy Alliance, LLC (Idaho Falls, ID)
12/ 883,002
September 15, 2010
GOVERNMENT RIGHTS This invention was made with government support under Contract Number DE-AC07-05ID14517 awarded by the United States Department of Energy. The government has certain rights in the invention.