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Broad spectrum antibiotic compounds and use thereof

United States Patent

July 5, 2016
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is assembled outside of the host membrane is described. Also described is the identification of homologous NRPS gene clusters from several additional microorganisms. The secondary metabolites produced by the NRPS gene clusters exhibit broad spectrum antibiotic activity. Thus, antibiotic compounds produced by the NRPS gene clusters, and analogs thereof, their use for inhibiting bacterial growth, and methods of making the antibiotic compounds are described.
Koglin; Alexander (Los Alamos, NM), Strieker; Matthias (Los Alamos, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
14/ 771,710
February 28, 2014
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.